Darius Gambino's practice includes many areas within both domestic and international intellectual property law.

Darius focuses his practice primarily on patent prosecution and litigation, trademark registration and enforcement, copyright registration and enforcement, trade secrets, licensing, opinions and due diligence investigations.

Darius concentrates his patent practice in the fields of electrical and mechanical engineering, including telecommunications, conditional access technologies, piezoelectric filters and sensors, semiconductor manufacture, electrical circuits, computer memories, computer hardware and software, business methods and construction materials. His trademark practice centers on procuring trademark registrations, counseling clients on enforcement strategies, conducting proceedings before the Trademark Trial and Appeal Board, and general litigation. Darius's copyright practice centers on copyright protection and enforcement, particularly in the fields of software, art and entertainment.

Darius is a frequent speaker, and has written extensively, in the areas of design patents and trade dress. Darius is the author of Trade Dress: Evolution, Strategy and Practice (2012) from LexisNexis.