In his almost 30-year career as a patent litigator, Tony Pezzano has successfully tried cases involving technology innovation across a diverse range of industries − particularly consumer, recreational and pharmaceutical products; chemical and petroleum products and processes; wireless telecommunication devices and equipment; computer software, hardware and systems; and printing engines and systems. He has appeared in numerous trials in the federal district courts, including both bench and jury trials, and International Trade Commission (ITC) Section 337 Hearings.

One of Tony's major areas of focus has been his representation of brand pharmaceutical companies in suits against generic drug companies under the Hatch-Waxman Act. He has served as lead counsel for brand pharmaceutical companies in over two dozen filed Hatch-Waxman cases during the past ten years involving antibiotic, antiviral, antifungal, anticoagulant and anti-organ transplant rejection drug products.

Another major area of focus for Tony has been his practice in ITC Section 337 investigations. Tony has successfully represented both Complainants and Respondents in ITC Section 337 investigations involving biologics, SeaDoos/WaveRunners, wireless communication devices, including mobile phones and tablets, computers routers and Segway/hoverboards. Tony is a Past President (2009) of the ITC Trial Lawyers Association.

Many significant companies around the world have called on Tony for representation in large-scale patent litigations in both the federal district courts and the ITC.  Few attorneys, if any, can match Tony's record of obtaining both injunctions in federal district court cases as well as exclusion and cease and desist orders in ITC Section 337 Investigations. Tony is ranked in the Legal 500 US 2019 and listed in the prestigious IAM Patent 1000 (2016–2018) rankings, which call him a "top-notch and untiring litigator…the first in the door and the last out."

Tony has also prosecuted patent and trademark applications and rendered opinions and counseling for US and foreign corporate clients involving intellectual property matters. He has had particular success in counselling pro bono small businesses through such programs as Start Small Think Big in obtaining patent and trademark protection for their businesses.