With continuing economic uncertainty, and other developments at home and around the world exacerbating mental health challenges globally, it is critical for businesses to create an environment for employees to seek and receive support, build resilience, and thrive. Below, we identify key issues for US employers to consider as they evaluate their mental health strategies and health plan coverage, communicate with employees, and manage compliance with obligations under the Americans with Disabilities Act (ADA) and other federal, state, and local laws that may require or permit leave and/or other accommodations based on mental health conditions.